Imaging of Auto-immune Encephalitis

Updated: January 22, 2025

The Neuroradiologist


Summary

The video discusses autoimmune encephalitis, a central nervous system disorder characterized by inflammation in the brain and spinal cord. It highlights the involvement of antibodies mediated by autoimmune antibodies and vasculitis development. The classification of autoimmune encephalitis is based on antibody targets, with a distinction between cytotoxic T-cell response and antibody-mediated types. Clinical case studies illustrate various presentations of autoimmune encephalitis, emphasizing the importance of accurate diagnosis and treatment. The video also covers specific cases such as anti-VGKC autoimmune encephalitis, cerebellar atrophy associated with ovarian teratoma, and anti-NMDA receptor encephalitis in young women and children with acute psychiatric symptoms.


Introduction to Autoimmune Encephalitis

Definition of autoimmune encephalitis, central nervous system disorders, and the entities involved such as inflammation in the brain and spinal cord, antibodies mediated by antimo antibodies, and vasculitis development.

Inflammatory CNS Disorders

Discussing inflammatory central nervous system disorders characterized by inflammation in the brain and spinal cord, targeting different brain structures, antibodies mediated by antimo antibodies, and dementing disorders like multiple sclerosis.

Autoimmune Encephalitis Types

Classification of autoimmune encephalitis based on antibody targets, distinguishing between two types: cytotoxic T-cell response and antibody-mediated, with better treatment response for the latter.

Case Study: Anti-VGKC Autoimmune Encephalitis

Case study of a 70-year-old woman with oncological history presenting with cognitive decline, MRI findings revealing anti-VGKC autoimmune encephalitis involving the mesial temporal region.

Case Study: Anti-NMDA Receptor Encephalitis

Case study of a 21-year-old female with hematologic disorder, developing acute behavioral changes, MRI showing cerebellar atrophy, and association with ovarian teratoma.

Case Study: Anti-CV2 Autoimmune Encephalitis

Case study of a patient with hyperemia and facial spasms, MRI showing demyelination, and association with seizures and chronic refractory epilepsy.

Case Study: Autoimmune Encephalitis with Rapid Progressive Atrophy

Case study of a 55-year-old male patient with hippocampal atrophy, extensive workup revealing no antibodies, emphasizing the diagnosis of autoimmune encephalitis.

NMDA Receptor Encephalitis Overview

Overview of anti-NMDA receptor encephalitis in young women and children, associated with autoimmune sepsis, and presenting with acute psychiatric symptoms.


FAQ

Q: What is autoimmune encephalitis?

A: Autoimmune encephalitis is a condition characterized by inflammatory central nervous system disorders involving the brain and spinal cord, where the immune system mistakenly attacks healthy brain cells.

Q: How is autoimmune encephalitis classified based on antibody targets?

A: Autoimmune encephalitis is classified based on antibody targets into two types: cytotoxic T-cell response and antibody-mediated, with the latter showing a better response to treatment.

Q: Can you explain the case study of the 70-year-old woman with anti-VGKC autoimmune encephalitis?

A: The case study involved a 70-year-old woman with cognitive decline and a history of cancer, showing MRI findings of anti-VGKC autoimmune encephalitis affecting the mesial temporal region.

Q: What are the characteristics of anti-NMDA receptor encephalitis?

A: Anti-NMDA receptor encephalitis primarily affects young women and children, often presenting with acute psychiatric symptoms and associated with autoimmune processes similar to sepsis.

Q: What are the common symptoms associated with autoimmune encephalitis?

A: Common symptoms of autoimmune encephalitis include cognitive decline, behavioral changes, seizures, dementing disorders like multiple sclerosis, and in some cases, atrophy in specific brain regions.

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